A lack of key proteins makes older people more susceptible to cancer
According to the statistics of the annual report of China's cancer registration in 2018, the incidence of malignant tumors gradually increases with age. The elderly over the age of 60 are the ones with the highest incidence of tumors, and the incidence peaks around the age of 80. Older people are at higher risk for cancer, do you know why older people are more susceptible to cancer?
A study published in the new issue of the American journal cell shows that the decrease in the amount of a protein called fiber-b may be the main culprit in the elderly's susceptibility to cancer. Professor Zheng yixian, a Chinese female scientist who led the study, said that during the aging process, immune organs age, a process known as immunosenescence.Immunosenescence induces a systemic inflammatory response that leads to a variety of diseases, including cancer. But little is known about the mechanism that causes inflammation and why it causes disease in old age.
Zheng and his team observed fat bodies of immune organs in wild fruit flies.Fat bodies act as body fat and liver. They found that malignant growths of the small intestine were possible in "old" fruit flies because of the gradual loss of the b-type nuclear fiber-layer protein in their fat cells as they aged.
Zheng said that a decrease in the b-type fibril protein would lead to the suppression of immune-related genes, which would lead to the production of a large number of inflammatory factors in the adipose body and secretion into the blood. These inflammatory factors, which are released continuously by the senescent fat body, suppress the local immune response in the small intestine and induce malignant growth of the small intestine. This finding suggests that the senescence of immune organs during mammalian senescence may be associated with decreased levels of b-type nuclear fibril protein. Aging of immune organs may lead to uncontrolled local immune responses in the small intestine and other organs, leading to organ dysfunction while increasing inflammatory responses.
“Our results provide a possibility to explain the systemic chronic inflammation and increased incidence of cancer in the elderly," said zheng. We hope that this finding in fruit flies will lead to the discovery in humans of the causes of low levels of chronic inflammation in old age and the mechanisms that cause geriatric disease."
Their findings offer a possible explanation for chronic inflammation and increased cancer rates in older people. It is hoped that this discovery will lead to the discovery in humans of the causes of low levels of chronic inflammation in old age and the mechanisms underlying the disease.
Wuxi Donglin Sci & Tech Development Co.,Ltd., have now developed a variety of ELISA Kits, if you want to know more about our product, welcome to visit our website: http://www.dldevelop.com
A study published in the new issue of the American journal cell shows that the decrease in the amount of a protein called fiber-b may be the main culprit in the elderly's susceptibility to cancer. Professor Zheng yixian, a Chinese female scientist who led the study, said that during the aging process, immune organs age, a process known as immunosenescence.Immunosenescence induces a systemic inflammatory response that leads to a variety of diseases, including cancer. But little is known about the mechanism that causes inflammation and why it causes disease in old age.
Zheng and his team observed fat bodies of immune organs in wild fruit flies.Fat bodies act as body fat and liver. They found that malignant growths of the small intestine were possible in "old" fruit flies because of the gradual loss of the b-type nuclear fiber-layer protein in their fat cells as they aged.
Zheng said that a decrease in the b-type fibril protein would lead to the suppression of immune-related genes, which would lead to the production of a large number of inflammatory factors in the adipose body and secretion into the blood. These inflammatory factors, which are released continuously by the senescent fat body, suppress the local immune response in the small intestine and induce malignant growth of the small intestine. This finding suggests that the senescence of immune organs during mammalian senescence may be associated with decreased levels of b-type nuclear fibril protein. Aging of immune organs may lead to uncontrolled local immune responses in the small intestine and other organs, leading to organ dysfunction while increasing inflammatory responses.
“Our results provide a possibility to explain the systemic chronic inflammation and increased incidence of cancer in the elderly," said zheng. We hope that this finding in fruit flies will lead to the discovery in humans of the causes of low levels of chronic inflammation in old age and the mechanisms that cause geriatric disease."
Their findings offer a possible explanation for chronic inflammation and increased cancer rates in older people. It is hoped that this discovery will lead to the discovery in humans of the causes of low levels of chronic inflammation in old age and the mechanisms underlying the disease.
Wuxi Donglin Sci & Tech Development Co.,Ltd., have now developed a variety of ELISA Kits, if you want to know more about our product, welcome to visit our website: http://www.dldevelop.com
